The Swiss Learning Health System (SLHS) is a collaborative project to establish a national platform for health systems and services research, policy and practice. The goal of the SLHS is to foster dialogue between stakeholders with the aim of developing and continuously integrating evidence-based solutions to current and future challenges in the health system. The SLHS relies on cyclical dynamics to identify issues, systematize relevant evidence, present alternative actions, select the best action, implement change, observe its consequences and, if necessary, revise and reshape responses.